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Thread: THC, THCV, CBG, CBC, CBN, and CBD

  1. #1
    Chew Guest

    Default THC, THCV, CBG, CBC, CBN, and CBD

    Hi folks,

    I found this online a few days ago. It's just a quick run down of the main cannabinoids and their medical benefits.

    THC, THCV, CBG, CBC, CBN, and CBD


    The most common cannabinoids in cannabis are THC, THCV, CBG, CBC, CBN, and CBD. Since the 1980’s, the discovery of cannabinoid receptor cells has produced multitudes of research of the effects and workings of canabinoids. It was first hypothesized that cannabinoids produced their physiological and behavorial effects via non-specific interaction with cell membranes. It is now known that cannbinoids interact with specific membrane-bound receptors commonly found in mammals, birds, fish and reptiles. At present, there are two known types of cannabinoid receptors, termed CB1 and CB2.
    When considering cannabis as an alternative medicine, it is important to remember that each cannabis strain has a unique chemical composition with varying amounts of THC, THCV, CBG, CBC, CBN, and CBD. Each strain can affect each person differently. Additionally, cultivation artists are taking cannabis strains and altering their genetic DNA by breeding the best characteristics from each plant. Thus, there are thousands of different variations of the cannabis plant.
    Our friends at Canna test provided us with a quick visual profile of the potency of cannabinoids, THCV, CBG, CBC, CBN, and CBD. Take some moments to look and become an educated cannabis connoisseur and start bragging to your friends about how much you know about this natural vegetative delight.


    Cannabinoid Effects, features & Medical Applications


    THC
    Tetrahydrocannabinol


    Brief:
    Responsible for the ‘’High’’-effect (psychotropic): it amplifies all sensory functions such as sight, hearing, color sensitivity and increases sexual arousal and a greater sense of well being. Produces strong feelings of euphoria. Sharpens the mind (cerebral) and promotes creativity. Analgesic (pain relieving), sedative, relaxing, energetic, promotes creativity.
    Discovery:
    1964, Gaoni and Mechoulm, Weizmann Institue Rehovot.


    Known Medicinal Benefits:



    • Anxiolytic – reduces the symptoms of anxiety
    • Neuroprotective – protects against nerve damage
    • Antispasmodic – relieves spasms and convulsions
    • Antiemetic – reduces vomiting and nausea
    • Analgesic – reduces pain
    • Appetite Stimulant – encourages eating and appetite
    • Antioxidant – fights free radicals in the bloodstream
    • Neuropathic analgesic – reduces pain from nerve damage
    • Bronchi-dialator -acts similarly to an inhaler to assist asthmatics with breathing
    • Anti-proliferative anticancer – reduces spread of certain cancers
    • Anti-inflammatory – reduces inflammation
    • Neurogenesis – promotes growth of new nerve tissue
    • Neuroprotectant – protects nerves from damage



    THCV Tetrahydrocannabivarin


    Brief:
    A psychoactive cannabinoid found along with THC in cannabis, research has shown that, in low doses, THCV will increase the effects of THC (strongly potentiating THC, provoking a heavy, stronger and faster “High”-effect) but in larger doses THCV is believed to oppose the effects of THC. Recent research into THCV has focused on its ability to reduce appetite.
    Discovery: 1970, Edward Gil and colleagues, UK
    Known medical benefits:



    • Apetite suppressant


    CBD Cannabidiol


    Brief:


    CBD works antagonistically in the micromolar range; it has an opposite effect of THC. It reduces the psychoactive effect, or the ‘’high’’ of THC, but in contrast, it will prolong slowly but increasingly this effect strongly. Not psychoactive. Effective against anxiety and stress (sedative). Strong muscle relaxation, especially on the smooth muscle fibers thus reducing muscle spasms.
    Discovery:
    1940, first isolated by Adams and colleagues, and stereochemically determined in 1963 by Mechoulam and Shvo.


    Known Medicinal Benefits:

    • Anxiolytic – reduces the symptoms of anxiety.
    • Antiepileptic - reduces seizures and convulsions
    • Neuroprotective – protects against nerve damage
    • Vasorelaxant – reduces tension in blood vessel walls
    • Antispasmodic – relieves spasms and convulsions
    • Anti-ischemic – reduces risk of artery blockage
    • Antiemetic – reduces vomiting and nausea
    • Antibacterial – kills surface bacteria
    • Antidiabetic – reduces blood sugar levels
    • Antipsoriatic – reduces effects of psoriasis
    • Antipsychotic – reduces psychosis including delusions or hallucinations
    • Analgesic – reduces pain
    • Bone-stimulant – promotes bone growth
    • Intestinal anti-prokinetic – reduces contractions in the small intestine
    • Anti-inflammatory – reduces inflammation
    • Antiproliferative anticancer – reduces spread of certain cancers
    • Immunosuppressant – reduces function in immune system





    CBN Cannabinol
    Brief:


    Mildly psychoactive, sedative, analgesic. CBN is, just like aspirin, a non-narcotic type analgesic, but 3x as strong. CBN is a breakdown product of THC. During storage (aging) CBN will slowly increase as THC deteriorates. CBN is effective at relieving tension headache.


    Discovery:
    1896, Wood and colleagues in Cambridge, the first natural cannabinoid to be obtained in pure form


    Known Medicinal Benefits:
    • Antispasmodic – relieves spasms and convulsions

    • Analgesic – reduces pain
    • Anti-inflammatory – reduces inflammation
    • Antioxidant – fights free radicals in the bloodstream



    CBG Cannabigerol
    Brief:


    Sedative, CBG tends to be higher in cannabis species without much THC (hemp varieties) and has hitherto been found only in trace amounts in most marijuana strains. CBG is the precursor form of a few of the other cannabinoids including THC and CBD. While little research has been conducted on CBG, it has been found to have medical properties including acting as a sedative, sleep inducer. Anti-microbial properties make it effective in treating bacterial infections.
    Discovery:


    1964 Gaoni and Mechoulam


    Known Medicinal Benefits:

    • Antibacterial – kills surface bacteria
    • Anti-microbial
    • Antiproliferative – inhibits cell growth
    • Bone Stimulant – promotes bone growth



    CBC Cannabichromene


    Brief:
    Non-psychoactive cannabinoid that also potentiates THC. It interacts in an as yet unknown way with THC to make the ‘’high’’ more intense and pronounced. it is also considered a strong sedative and analgesic.


    Discovery:
    1966 independently reported by Claussen and colleagues as well as Gaoni and Mechoulam.


    Known Medicinal Benefits:

    • Anti-inflammatory – reduces inflammation
    • Analgesic – reduces pain
    • Bone Stimulant – promotes bone growth
    • Antimicrobial – kills bacteria or fungi
    • Antiproliferative – inhibits cell growth
    • Vasoconstriction - constricting of the blood vessels
    • Effective treatment of migraine





    THCA
    D9-Tetrahydrocannabinolic Acid


    Brief:
    D9-THC has two acidic analogs: D9-THCA A and D9-THCA Bc. D9-THCA


    Discovery:
    D9-THCA A, first extracted by Korte and coworkers (1965), was isolated as a pure compound in 1967 by Nishioka’s group. In 1969, Mechoulam and coworkers reported the isolation of D9-THCA B.
    Known medical benefits:



    • Anti-proliferative
    • Anti-spasmodic
    • Anti-inflamatory



    CBDA Cannabidiolic Acid
    Brief:


    The first cannabinoid acidc to be discovered, Together with CBD, CBDA is the main component of glandular hairs (up to 15%). In fresh plant material, 95% of CBD exists as its acid.
    Discovery: 1955, Isolated by Krejci and Santavy.


    Known Medical Benefits:
    • Anti-proliferative actions


    References Angelo A. Izzo1,4, Francesca Borrelli1,4, Raffaele Capasso1,4, Vincenzo Di Marzo2,4 and Raphael Mechoulam3. (2009) Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. TIPS-730. 13
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy 2 Institute of Biomolecular Chemistry, National Research Council, Pozzuoli (NA), Italy 3Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty, Jerusalem, Israel 4Endocannabinoid Research Group, Italy
    R.J. Glas Alpha Nova Pharma Wageningen

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  3. #2

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    I'm going to sticky this information!
    "Accuse the other side of that which you are guilty."
    (Joseph Goebbels)

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    Another Very useful post Chew & Well worthy of A stick!!

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  7. #4

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    Thanks Chew for sharing such awesome information ...theres increasing interest for this THCv and what it can do for weight loss 😊

    Check out my new QuadStrain grow 😉 :
    https://www.thctalk.com/cannabis-foru...d.php?t=147030
    and my previous TriStrain grow 😉:
    https://www.thctalk.com/cannabis-foru...d.php?t=134573
    Check out my current TriStrain grow

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  9. #5
    Mr Legend Guest

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    Nice one Chew...

    I've been experimenting with acid forms of cannabinoids lately and doing some fresh plant ultrasonic extraction for a very young girl with spastic MS, her condition improved considerably after only a month of capsulated oral therapy and most importantly without any psychoactive effects...
    Spasms are down by more than 70% and she finally sleeps through the night without waking up, poor soul didn't have a good nights rest in her life...

    It's a good example that decarboxylation of cannabinoids is not always necessary and that different conditions require different approach, acid forms of cannabinoids are just as effective in treating most conditions and with no psychoactive effects too which is sometimes very important...

    Also GPR55 receptor has been officially confirmed as a third major cannabinoid receptor so more and more official research is pointed in that direction, it's gonna be a game changer for sure...

    Mon the oil and home grown medicine...

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    Quote Originally Posted by Dexter McPherson View Post
    Nice one Chew...

    I've been experimenting with acid forms of cannabinoids lately and doing some fresh plant ultrasonic extraction for a very young girl with spastic MS, her condition improved considerably after only a month of capsulated oral therapy and most importantly without any psychoactive effects...
    Spasms are down by more than 70% and she finally sleeps through the night without waking up, poor soul didn't have a good nights rest in her life...

    It's a good example that decarboxylation of cannabinoids is not always necessary and that different conditions require different approach, acid forms of cannabinoids are just as effective in treating most conditions and with no psychoactive effects too which is sometimes very important...

    Also GPR55 receptor has been officially confirmed as a third major cannabinoid receptor so more and more official research is pointed in that direction, it's gonna be a game changer for sure...

    Mon the oil and home grown medicine...
    Thanks bro for sharing your experience. My question to you and all the experienced and knowledgeable gentlemen, is:
    My understanding is that non-decarbed cannabis oil in an alcohol tincture (green dragon) will undergo full natural decarboxylation in about 4 months becoming golden dragon ..... does this process occur in coconut oil infused cannabis oil? (My guess would be that it does, but maybe requiring longer time than 4 months?)
    Thank you guys in advance 😊

    Check out my new QuadStrain grow 😉 :
    https://www.thctalk.com/cannabis-foru...d.php?t=147030
    and my previous TriStrain grow 😉:
    https://www.thctalk.com/cannabis-foru...d.php?t=134573

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  13. #7
    Chew Guest

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    Quote Originally Posted by Dexter McPherson View Post
    Nice one Chew...

    I've been experimenting with acid forms of cannabinoids lately and doing some fresh plant ultrasonic extraction for a very young girl with spastic MS, her condition improved considerably after only a month of capsulated oral therapy and most importantly without any psychoactive effects...
    Spasms are down by more than 70% and she finally sleeps through the night without waking up, poor soul didn't have a good nights rest in her life...

    It's a good example that decarboxylation of cannabinoids is not always necessary and that different conditions require different approach, acid forms of cannabinoids are just as effective in treating most conditions and with no psychoactive effects too which is sometimes very important...

    Also GPR55 receptor has been officially confirmed as a third major cannabinoid receptor so more and more official research is pointed in that direction, it's gonna be a game changer for sure...

    Mon the oil and home grown medicine...
    If only it was rescheduled huh? I've been reading about GPR55 too. Exciting mate
    Im running some oil next week that i shall not be decarbing for a topical cream. I'm looking forward to see what it can do. My Mum has Parkinson's, aches and pains never let up. I tried to get her on the oil but she's lost all strength in her hands and arms and can't put the suppositories in herself so she quit after only a few days. It was such a shame mate because My dad and I could see her relaxing even after 1x dose. I'm hoping the topical will help with the pain. I'm going to make three batches, debarbed, part decarbed and non decarbed. Should be a good test

    Great news on the child mate, top man
    Last edited by Chew; 26-09-16 at 03:04 PM.

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  15. #8
    Mr Legend Guest

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    Quote Originally Posted by DrCannaPath View Post
    Thanks bro for sharing your experience. My question to you and all the experienced and knowledgeable gentlemen, is:
    My understanding is that non-decarbed cannabis oil in an alcohol tincture (green dragon) will undergo full natural decarboxylation in about 4 months becoming golden dragon ..... does this process occur in coconut oil infused cannabis oil? (My guess would be that it does, but maybe requiring longer time than 4 months?)
    Thank you guys in advance 😊

    Check out my new QuadStrain grow 😉 :
    https://www.thctalk.com/cannabis-foru...d.php?t=147030
    and my previous TriStrain grow 😉:
    https://www.thctalk.com/cannabis-foru...d.php?t=134573
    You're right on the money Doc, cannabinoids will decarb on their own in the presence of oxygen especially when in alcohol suspension...
    If you extract with coconut or olive oil and keep the solution sealed and refrigerated (not frozen) it can last for a year minimum...

    Quote Originally Posted by Chew View Post
    If only it was rescheduled huh? I've been reading about GPR55 too. Exciting mate
    Im running some oil next week that i shall not be decarbing for a topical cream. I'm looking forward to see what it can do. My Mum has Parkinson's, aches and pains never let up. I tried to get her on the oil but she's lost all strength in her hands and arms and can't put the suppositories in herself so she quit after only a few days. It was such a shame mate because My dad and I could see her relaxing even after 1x dose. I'm hoping the topical will help with the pain. I'm going to make three batches, debarbed, part decarbed and non decarbed. Should be a good test

    Great news on the child mate, top man
    Get yourself an ultrasonic cleaner bro, I bought a medical grade 2l capacity device for 160€ and it does wonders both for fresh extraction and leposomal encapsulation...
    If you do a fresh herb extract your mum could dose orally without side effects...
    I'm hoping to get some lab access at a friends university soon, he's a professor there and says they got all the gear we need... Fingers crossed bro... 😊✌️

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  17. #9
    Chew Guest

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    Quote Originally Posted by Dexter McPherson View Post
    You're right on the money Doc, cannabinoids will decarb on their own in the presence of oxygen especially when in alcohol suspension...
    If you extract with coconut or olive oil and keep the solution sealed and refrigerated (not frozen) it can last for a year minimum...


    Get yourself an ultrasonic cleaner bro, I bought a medical grade 2l capacity device for 160€ and it does wonders both for fresh extraction and leposomal encapsulation...
    If you do a fresh herb extract your mum could dose orally without side effects...
    I'm hoping to get some lab access at a friends university soon, he's a professor there and says they got all the gear we need... Fingers crossed bro... ✌️
    Its something I have been considering Dexter but funds are tight
    Can you PM me the one you have as I would rather buy one that's tried and tested by a good source

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  19. #10
    Chew Guest

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    It's nice to have others with such a keen interest in this. I was getting lonely by myself! Lol

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  21. #11

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    Its fascinating Chew, when you look at prescription drugs and their problems, then what a plant can do! I would appreciate an explanation of what an ultrasonic cleaner actually does with your herb???

    I looked the liposomal extraction up

    The heart of liposomal encapsulation technology comes down to liposomes, but what exactly are they? Here is a quick guide to what liposomes are, how they work and how they are made.

    Essentially, Liposomal Encapsulation Technology consists of microscopic healthy fat particles which are made up of phospholipids along with water soluble vitamins and minerals. This technology has been used for many years as a way of delivering small amounts of therapeutic substances to the specific tissues of the body, without affecting any other part of the body.

    How Does it Work?
    How it works is that the liposomes form a microscopic bubble made from layers of special types of molecules known as phospholipids. It is a membrane, very similar to the type of membrane that surrounds the cells within your body. This membrane contains and protects whatever substance is inside.

    Many years ago, researchers discovered that these liposomes could be filled with therapeutic agents and nutrients. The membrane would hold in the substance while the supplement was ingested and would not release it until it had reached the appropriate tissues or body part.

    This incredible technology works because of a natural phenomenon that actually makes life as we know it possible. This is the natural behaviour of phospholipids to form tiny bubbles when they are within an aqueous solution under the right conditions. These small bubbles are called “liposomes’ and they become automatically filled with the aqueous solution that they were in before they were formed. So, for example, when they are within a Vitamin C supplement solution they become filled to the brim with liquid Vitamin C. These little bubbles of Liposomal Vitamin C stay intact until they are delivered directly to the right part of the body

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  23. #12
    Chew Guest

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    Quote Originally Posted by Dutchcourage View Post
    Its fascinating Chew, when you look at prescription drugs and their problems, then what a plant can do! I would appreciate an explanation of what an ultrasonic cleaner actually does with your herb???

    I looked the liposomal extraction up

    The heart of liposomal encapsulation technology comes down to liposomes, but what exactly are they? Here is a quick guide to what liposomes are, how they work and how they are made.

    Essentially, Liposomal Encapsulation Technology consists of microscopic healthy fat particles which are made up of phospholipids along with water soluble vitamins and minerals. This technology has been used for many years as a way of delivering small amounts of therapeutic substances to the specific tissues of the body, without affecting any other part of the body.

    How Does it Work?
    How it works is that the liposomes form a microscopic bubble made from layers of special types of molecules known as phospholipids. It is a membrane, very similar to the type of membrane that surrounds the cells within your body. This membrane contains and protects whatever substance is inside.

    Many years ago, researchers discovered that these liposomes could be filled with therapeutic agents and nutrients. The membrane would hold in the substance while the supplement was ingested and would not release it until it had reached the appropriate tissues or body part.

    This incredible technology works because of a natural phenomenon that actually makes life as we know it possible. This is the natural behaviour of phospholipids to form tiny bubbles when they are within an aqueous solution under the right conditions. These small bubbles are called “liposomes’ and they become automatically filled with the aqueous solution that they were in before they were formed. So, for example, when they are within a Vitamin C supplement solution they become filled to the brim with liquid Vitamin C. These little bubbles of Liposomal Vitamin C stay intact until they are delivered directly to the right part of the body
    See Dutch, you're getting the bug...Once you start, you can't stop. The possibilities of cannabis are endless, nearly! lol
    You wouldn't believe the size of my note book and the endless hours researching. Is all good. We can literally change people's lives here

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    I believe it Chew and when Ive got a couple more grows in that exactly where I am heading for mate, "making a difference"

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  27. #14
    Chew Guest

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    Quote Originally Posted by Dutchcourage View Post
    I believe it Chew and when Ive got a couple more grows in that exactly where I am heading for mate, "making a difference"
    Good for you mate. Making a difference to even one life is so rewarding. I hate seeing people suffer...
    Mon the plant

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    Quote Originally Posted by Chew View Post
    Good for you mate. Making a difference to even one life is so rewarding. I hate seeing people suffer...
    Mon the plant
    Same,Same Mon the plant

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    Great thread, great info, great guy.....keep it up Chew

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  33. #17
    Mr Legend Guest

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    Quote Originally Posted by Chew View Post
    It's nice to have others with such a keen interest in this. I was getting lonely by myself! Lol
    Sorry I left you hanging Chew but last time we were down I joined my local grow forum out of boredom and found a sorry looking medical section, it took me a long time to get them up to speed cause they were still on naphtha extraction RSO and straight oil oral dosing...
    Nobody ever heard of carrier oils, liposomal encapsulation or competitive inhibition, bioavailability wasn't even a subject...

    I've been doing bunch of tests runs with different ratios of cco/carrier/lecithin/alcohol after trying a 100mg dose that still had some alcohol in, it hit me so hard and fast I couldn't believe mate so I had to experiment a bit... I'm somewhere between 10-15% alcohol now and it definitely has dramatic effect on absorption speed and potency, I'm using coconut oil as carrier as I can only judge psych effects until I have lab access...

    I'll open another topic and write my ramblings there mate cause I keep messing up yours...

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    Want to thank you gentlemen for all your tireless research I have friends who are sick and repeat all your findings to them. I hope they take it to heart but a lot of people I know just aren't willing to listen. They are old school Marijuana has only one purpose to get high. I have converted a few but it is a never ending battle with some of them. Again keep up the amazing work. Peace to you and your. Also chew all the best and prayers to your mother.

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  37. #19
    Chew Guest

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    Quote Originally Posted by Dexter McPherson View Post
    Sorry I left you hanging Chew but last time we were down I joined my local grow forum out of boredom and found a sorry looking medical section, it took me a long time to get them up to speed cause they were still on naphtha extraction RSO and straight oil oral dosing...
    Nobody ever heard of carrier oils, liposomal encapsulation or competitive inhibition, bioavailability wasn't even a subject...

    I've been doing bunch of tests runs with different ratios of cco/carrier/lecithin/alcohol after trying a 100mg dose that still had some alcohol in, it hit me so hard and fast I couldn't believe mate so I had to experiment a bit... I'm somewhere between 10-15% alcohol now and it definitely has dramatic effect on absorption speed and potency, I'm using coconut oil as carrier as I can only judge psych effects until I have lab access...

    I'll open another topic and write my ramblings there mate cause I keep messing up yours...
    There was a debate on whether alcohol should be added to the Bio Bomb recipes or not. It was a really interesting read but something I've not tried myself so I look forward to to reading about your experiences with it.

  38. The Following 2 Users Say Thank You to Chew For This Useful Post:

    DrCannaP (27-09-16), lostorstolen (27-09-16)

  39. #20
    Chew Guest

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    Quote Originally Posted by Dexter McPherson View Post
    Sorry I left you hanging Chew but last time we were down I joined my local grow forum out of boredom and found a sorry looking medical section, it took me a long time to get them up to speed cause they were still on naphtha extraction RSO and straight oil oral dosing...
    Nobody ever heard of carrier oils, liposomal encapsulation or competitive inhibition, bioavailability wasn't even a subject...

    I've been doing bunch of tests runs with different ratios of cco/carrier/lecithin/alcohol after trying a 100mg dose that still had some alcohol in, it hit me so hard and fast I couldn't believe mate so I had to experiment a bit... I'm somewhere between 10-15% alcohol now and it definitely has dramatic effect on absorption speed and potency, I'm using coconut oil as carrier as I can only judge psych effects until I have lab access...

    I'll open another topic and write my ramblings there mate cause I keep messing up yours...
    Surprising how many forums have little or no info whatsoever. We had a few days we were down around a week ago and i stubbled across a forum and found a guy trying to fight liver cancer, stage 4. He was ingesting 1.25 grams of straight oil per day spilt into 3 doses!

  40. The Following User Says Thank You to Chew For This Useful Post:

    lostorstolen (27-09-16)

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