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Thread: Marijuana cuts lung cancer tumor growth Harvard Study

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    Talking Marijuana cuts lung cancer tumor growth Harvard Study

    I wonder what has happened with this research from 2007? It was talked about again in 2009 with a reprint of the article but nothing since. Does anyone else know?

    They say this is the first set of experiments to show that the compound, Delta-tetrahydrocannabinol (THC), inhibits EGF-induced growth and migration in epidermal growth factor receptor (EGFR) expressing non-small cell lung cancer cell lines. Lung cancers that over-express EGFR are usually highly aggressive and resistant to chemotherapy.

    THC that targets cannabinoid receptors CB1 and CB2 is similar in function to endocannabinoids, which are cannabinoids that are naturally produced in the body and activate these receptors. The researchers suggest that THC or other designer agents that activate these receptors might be used in a targeted fashion to treat lung cancer.

    "The beauty of this study is that we are showing that a substance of abuse, if used prudently, may offer a new road to therapy against lung cancer," said Anju Preet, Ph.D., a researcher in the Division of Experimental Medicine.

    Acting through cannabinoid receptors CB1 and CB2, endocannabinoids (as well as THC) are thought to play a role in variety of biological functions, including pain and anxiety control, and inflammation. Although a medical derivative of THC, known as Marinol, has been approved for use as an appetite stimulant for cancer patients, and a small number of U.S. states allow use of medical marijuana to treat the same side effect, few studies have shown that THC might have anti-tumor activity, Preet says. The only clinical trial testing THC as a treatment against cancer growth was a recently completed British pilot study in human glioblastoma.

    In the present study, the researchers first demonstrated that two different lung cancer cell lines as well as patient lung tumor samples express CB1 and CB2, and that non-toxic doses of THC inhibited growth and spread in the cell lines. "When the cells are pretreated with THC, they have less EGFR stimulated invasion as measured by various in-vitro assays," Preet said.

    Then, for three weeks, researchers injected standard doses of THC into mice that had been implanted with human lung cancer cells, and found that tumors were reduced in size and weight by about 50 percent in treated animals compared to a control group. There was also about a 60 percent reduction in cancer lesions on the lungs in these mice as well as a significant reduction in protein markers associated with cancer progression, Preet says.

    Although the researchers do not know why THC inhibits tumor growth, they say the substance could be activating molecules that arrest the cell cycle. They speculate that THC may also interfere with angiogenesis and vascularization, which promotes cancer growth.

    Preet says much work is needed to clarify the pathway by which THC functions, and cautions that some animal studies have shown that THC can stimulate some cancers. "THC offers some promise, but we have a long way to go before we know what its potential is," she said.

    http://current.com/1r1vm4c

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  3. #2

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    I wish more money was put into research like this. Someone on here needs to win the euromillions.

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    Its something i will do if ever i win the bugger! lol

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    fuck that....... if i win it, i'll buy an island, make it leagl and we can all go live there in peace and smoke our brains out!
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    lol even better!

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    they reilsed the active fomrula c21h30o2 was probalby the main cause of this so they bio engineered it and found out the bio enginered one doesnt work only the one in cannabis does so they chose to give up as they cant sell cannabis if its a plant that comes from the ground

    natural and herbal treatmeant is not looked into as there is no profit to be made init
    Last edited by C21H30O2; 02-06-12 at 07:45 PM.
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    Unfotunatly it will take a very rich and generous donor that won't expect much

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    Interesting thread.

    There should be more freedom to study

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    Thanks for the info

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    I figure as others have stated, when there isn't a lot of profit to be made most people just ignore viable and life-saving research. I figure now that it's being legalized in so many states I think the government and hospitals are realizing that in fact, there is quite a lot of profit to be made you know, if they add a good bit of taxes and "hospital fees" into the mix. Although it's unfortunate, at least it's a sign that it may be taken more seriously for medicinal purposes.

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    Why has this study not been updated? If it really works the drug companies would be testing it and figuring out how to make money. I wonder why this 'study' has not been published more. Maybe it is false. Anytime I see a study with the words. "The drug companies don't want you to see this" I've concluded the study is bogus.

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    Or money.... UK is biggest exporter of medical cannabis yet we cand have it...
    Studies are being made hence why people can go for clinical trials of cannabis oil on on cancers

    Your looking in the wrong places if u can't find new

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    Cannabis really does seem to be a panacea of sorts. It treats so many things, yet we can't have it. A more paranoid person might read something into that....

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    Default Marijuana Cures Cancer

    Medical marijuana is known to cure multiple forms of cancers and various other ailments.

    The saddest part is that this medicine is banned in several parts of the world under influence of pharama companies and wine industry.

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    I personally think it's the big pharma companies and alcohol companies that hold back medicinal cannabis and will continue to do so until they figure out how they can make huge profits from it, jmo, G'.
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    Quote Originally Posted by G' View Post
    I personally think it's the big pharma companies and alcohol companies that hold back medicinal cannabis and will continue to do so until they figure out how they can make huge profits from it, jmo, G'.
    Economically driven decision, not quality. The rich get richer, the poor get poorer.
    Fight for your health.

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    Quote Originally Posted by Valentina View Post
    Economically driven decision, not quality. The rich get richer, the poor get poorer.
    There are a number of 30 minute interviews related to people who have treated lung cancer out of a total of over 200 interviews with people with a wide variety of other cancers and serious health problems on the Cannabis Health Radio channel on YouTube. Some people used just cannabis in different forms depending on the condition and some in conjunction with conventional treatments. There is also a video on YouTube made by the son of a man with lung cancer who was if i recall given days to live in hospital. The Son crossed state lines to get RSO, after taking the oil his father left hospital and over time his health improved significantly, ironically he passed away three years later not due to cannabis or to the cancer but due to the changes chemo caused to his heart.
    Regards

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    Since this website does not allow external links,

    just look at hemp capacitor, anyways below is from bbc news about hemp being a big player in capacitors.

    Hemp fibres 'better than graphene'
    By James Morgan
    Science reporter, BBC News, San Francisco
    13 August 2014

    The waste fibres from hemp crops can be transformed into high-performance energy storage devices, scientists say.

    They "cooked" cannabis bark into carbon nanosheets and built supercapacitors "on a par with or better than graphene" - the industry gold standard.

    Electric cars and power tools could harness this hemp technology, the US researchers say.

    They presented their work at the American Chemical Society meeting in San Francisco.

    "People ask me: why hemp? I say, why not?" said Dr David Mitlin of Clarkson University, New York, who describes his device in the journal ACS Nano.

    "We're making graphene-like materials for a thousandth of the price - and we're doing it with waste.

    "The hemp we use is perfectly legal to grow. It has no THC in it at all - so there's no overlap with any recreational activities."

    Secret sauce
    In countries including China, Canada and the UK, hemp can be grown industrially for clothing and building materials.

    But the leftover bast fibre - the inner bark - typically ends up as landfill.

    Dr Mitlin's team took these fibres and recycled them into supercapacitors - energy storage devices which are transforming the way electronics are powered.

    Conventional batteries store large reservoirs of energy and drip-feed it slowly, whereas supercapacitors can rapidly discharge their entire load.

    They are ideal in machines that rely on sharp bursts of power. In electric cars, for example, supercapacitors are used for regenerative braking.

    Releasing this torrent requires electrodes with high surface area - one of graphene's many phenomenal properties.

    Stronger than diamond, more conductive than copper and more flexible than rubber, the "miracle material" was the target of a £50m investment by UK Chancellor George Osborne.

    But while this carbon monolayer is the state-of-the-art material for commercial supercapacitors, it is prohibitively expensive to produce.

    Finding cheap, sustainable alternatives is the speciality of Dr Mitlin's former research group at the University of Alberta.

    They have experimented with all flavours of biowaste - from peat moss to eggs. Most recently, they turned banana peel into batteries.

    "You can do really interesting things with bio-waste. We've pretty much figured out the secret sauce of it," said Dr Mitlin.

    The trick is to tailor the right plant fibre to the right electrical device - according to their organic structure.

    "With banana peels, you can turn them into a dense block of carbon - we call it pseudo-graphite - and that's great for sodium ion batteries," he explained.

    "But if you look at hemp fibre its structure is the opposite - it makes sheets with high surface area - and that's very conducive to supercapacitors."

    The first step, he explained, "is to cook it - almost like a pressure cooker. It's called hydrothermal synthesis.

    "Once you dissolve the lignin and the semicellulose, it leaves these carbon nanosheets - a pseudo-graphene structure."

    By fabricating these sheets into electrodes and adding an ionic liquid as the electrolyte, his team made supercapacitors which operate at a broad range of temperatures and a high energy density.

    Direct comparisons with rival devices are complicated by the variety of measures for performance.

    But Mitlin's peer-reviewed journal paper ranks the device "on par with or better than commercial graphene-based devices".

    "They work down to 0C and display some of the best power-energy combinations reported in the literature for any carbon.

    "For example, at a very high power density of 20 kW/kg (kilowatt per kilo) and temperatures of 20, 60, and 100C, the energy densities are 19, 34, and 40 Wh/kg (watt-hours per kilo) respectively."

    Image copyrightSPL
    Fully assembled, their energy density is 12 Wh/kg, which can be achieved at a charge time less than six seconds.

    Growth industry
    "Obviously hemp can't do all the things graphene can," Dr Mitlin concedes.

    "But for energy storage, it works just as well. And it costs a fraction of the price -$500-1,000 a tonne."

    Having established a proof of principle, his start-up company Alta Supercaps is hoping to begin small-scale manufacturing.

    It plans to market devices to the oil and gas industries - where high-temperature operation is a valuable asset.

    His move to the US coincides with a change in regulatory attitudes - with signs that hemp could be making a comeback.

    In China the crop is widely cultivated, and in Canada, the industry for textiles is growing.

    "Fifty miles down the road from my house in Alberta there was an agricultural hemp processing facility. And all that bast fibre - it just sits in a high bay, and they don't know what to do with it," Dr Mitlin told BBC News.

    "It's a waste product looking for a value-added application. People are almost paying you to take it away."

    And if the technology really takes off - it could help economies, he argues.

    "It's a robust plant - you can even grow it in Alberta, Manitoba.

    "A lot of farmers would be thrilled to grow hemp."

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